"The Blues" is a very limited form, yet it has provided about a century of wonderful creative music.
If I'm writing a string quartet, I don't complain that a particular note can't be sung by a gospel choir instead of a cello. Just as a painter doesn't complain about the canvas being 2 dimensional.
Of course DAW's can handle key changes.
The issue is that working full time in a DAW environment seems to have a tendency to displace a number of important musical sensibilities.