I take methylphenidate slow release, and have for several years now. If I take an extended holiday, the first ~week back definitely feels like there is a stronger effect, but days when I take it vs don't are very noticeable in how difficult my day is. People in my personal life can call it out when I am unmedicated, my sleep is worse, chores don't get done, I waste more time at work, I go more crazy at social events and so on.

I really hope it keeps working in the longer term because it's been life changing so far.