I would advice you to at least use some kind of web component wrapper. I have used https://lit.dev/ a lot, even to build a large app and it works really well. You can get started very quickly and the experience stay true to the underlying platform.

I think lit is really a library that deserves more attention since it's so good.

Unless you simply want server rendered html, you can achieve that easily with htmx to get a bit better experience. Then you may use whatever language you want and just return html.