>Firstly, you can't predict the future so really you're working off your biases.

Um, are you saying that this implies that people should just throw up their hands and donate to whatever causes since who knows? Surely not. Once we acknowledge that these questions can be tackled empirically, that's what EA tries to do. Is there room for bias in this process? Absolutely. Does that justify embracing some sort of epistemic nihilism? Absolutely not.