Males who take analbolic steroids can permamently supress natural testosterone production. There is an injectable that they can take after they stop taking testosterone which restarts the natural testosterone production, but some guys are not careful enough to do this which can lead to permanant damage -> this leads to low or no testosterone production, which in males causes depression since the male body is designed for a certain physiological dose of T in the blood -> if it's too low -> damage, depression, illness,...

Messing with hormones is one of the most dangerous things as you can:

a) Cause the body to shutdown the natural production, which can lead to the death/diminishing of the tissue that produces it.

b) You can cause a hormonal disruption system-wide, a domino like chain effect which can wreck havok on the body.

To believe that one can simple "adjust a bit of hormone A, then a bit of B" and that there would be no side effects is horribly naive.

But modern doctors are horrible naive, as anyone who has done reading a lot around this topic will naturaly come to understand.

First you get pill A, then you get pill B to manage side effects of pill A, then you need pill C to manage side effects of pill B, then you need a surgery because pill A supressed cholesterol too much which is a crucial building blocks of the body (50% of each cell membrane is cholesterol for example, so tell me again how cholesterol is bad), then you need pills D, E, F...