Right now it's fairly common in software development to have a debug build and a release build with potentially different optimisation levels. So that's two builds to manage - if we could build with lower optimisation and still effectively run at higher levels then that's a whole load of build/test simplification.
Moreover, debugging optimised binaries is fiddly due to information that's discarded. Having the original, unoptimised, version available at all times would give back the fidelity when required (e.g. debugging problems in the field).
Java effectively lives in this world already as it can use high optimisation and then fall back to interpreted mode when debugging is needed. I wish we could have this for C/C++ and other native languages.