This post pretty much reflects my observations back when I was job hunting a year or so ago. I had a good amount of experience, was willing to relocate, wasn't looking for a telecommuting position, and was very flexible on salary. I advertised myself to several high-profile companies, many of which have affiliations with YC. None of them were through recruiters, and a few were even direct contacts with some core developers happening to advertise the company on twitter: cough Disqus cough.
The number of responses I received even acknowledging that they got my personalized cover letter and resume? Zero. Nada. Zilch.
I ended up getting a job by being referred through a friend to a company completely outside of the whole startup/valley/YC culture. The absolute worst thing you can do is have your job search and advertisements become a black hole.
So every company reading this comment: get your shit together.