Nope. Flexbox makes it easy to just use plain CSS nowadays. No more SASS or any other preprocessor nonsense. Not even a fan of Tailwind (too much complexity for dubious benefit).

CSS has never been better and now there's just the right amount of it. Also now that there's no more need for crazy JS hacks, you can have just a little bit of JS for interactivity and that's it. Front end development is finally pleasant again.