I've felt the same way for over 15 years, no solution in sight.
I've tried the meds for many years, I've tried therapy, cognitive behavioural therapy and many other things and nothing has worked.
I've also started to feel less interested in things I thought I was interested in.
The only thing really keeping me alive and fighting is my girlfriend and my family, which I have pretty poor contact with if I'm honest, but I still don't want to upset them.