1. Disable replies - end to the constant arguing and conflicts.
2. Disable retweets - end to the "aggregator" accounts.
3. Disable likes - end to vanity posting.
4. Adjust the ranking algorithm - users who post a lot and use a lot of hashtags are downweighted.
The goal would be is to make twitter a platform for people to share updates about their work. Artist share their paintings, scientists their articles, developers - the new versions of their software, etc.
This would kill twitter thou.