"I hate those MegaUpload people. I'll issue a false take-down notice to shut them up! Bwahahaha! <twirls mustache>"
and
"Oh. Another hit from our crappy YouTube crawler bot. <rubber stamps take-down notice>"
There is a difference between malice directed towards MegaUpload and (willful) negligence.
[ Also, don't reply with something stupid like, "but that won't hold up in court." Because a careful reading of the above text will reveal a lack of me making any such statement. ]