1. Some application processes ask me to upload my resume and then want me to manually enter it again in a series of web forms. I'm not interested in spending 30+ minutes manually copying and pasting the resume I just uploaded. I figure that lack of common sense is systemic in the company, so I don't want to work there.
2. Some companies use third-party services, like icimi.com. If I submit two or three resumes through these third-party services and fail to receive a response, I never apply for other companies that use these same services.