You might be interested in this little tool of mine: https://github.com/majewsky/jack-autoplug - It's using the JACK API, so it works with PipeWire out of the box. I run instances of this tool as systemd services, grouped into targets. To switch pluggings on and off on demand, I have global keybinds connected to scripts like this:

  #!/bin/sh
  set -euo pipefail
  if systemctl --user is-active --quiet autoplug-group.target; then
    systemctl --user stop autoplug-group.target
  else
    systemctl --user start autoplug-group.target
  fi

I haven't tried it yet, but wouldn't a patchbay profile suffice?