Nothing prevents you from doing what Tucci does for a few days -- stay in expensive nice places, find the good and overpriced restaurants, travel to a small village somewhere, and ignore the mess and noise around you. It won't be cheap, and you won't have a cleaning crew prettying up the scene or removing the guy peeing in public in the corner before you walk in, but hey.

I haven't been in the US in a while, but from recent news mentioned even here in HN, if you're visiting Italy from Seattle these days, you'd find the air in Northern Italy ( which is the worst in the EU ) actually an improvement, apparently ?

Same as if you come from San Francisco, looks like Rome or Naples will be safer from that perspective too. Local homeless, trash and litter, ubiquitous rude manners and insane murderous traffic be what they may.

Since you haven't been in Europe, may I also suggest to visit Spain, for actually friendly people and good food not so overpriced as the Italian, certainly not leaving without seeing at least Paris, and maybe look at some fairy tale towns and landscapes in central Europe; Czech Republic, Austria, Slovenia ...