But you can't tweak Newton's laws, because we know Newton's laws aren't the right laws of gravity. The laws of General Relativity make better predictions. So what you would have to tweak would be the laws of GR.
And the basic problem with doing that is that you can't just tweak a single parameter in GR to get the kind of modified behavior that MOND does with Newtonian dynamics. In GR, there simply isn't any such free parameter to tweak. You have to adjust the whole theory. And any such adjustment ends up looking just like dark matter: you have to invent new fields or new forms of stress-energy that we have no other evidence for. And that destroys the whole point of MOND, which was to just modify the laws of gravity without changing our assumptions about what matter and energy is present in the universe. If you're going to have to add new forms of matter and energy anyway, why not just stick to that and keep the laws of gravity the same? That's what the dark matter hypothesis amounts to, and why it's actually the simpler hypothesis once GR is taken into account.