During the entire conflict period, from 14 April 2014 to 31 December 2021, OHCHR recorded a total of 3,106 conflict-related civilian deaths (1,852 men, 1,072 women, 102 boys, 50 girls, and 30 adults whose sex is unknown). Taking into account the 298 deaths on board Malaysian Airlines flight MH17 on 17 July 2014, the total death toll of the conflict on civilians has reached at least 3,404. The number of injured civilians is estimated to exceed 7,000.
These monthly reports by the OHCHR give a breakdown of the specific causes and locations of casualties. From an earlier report:
During the last six months, from 1 October 2019 to 31 March 2020, 84.4 per cent of civilian casualties resulting from shelling and SALW fire were recorded in territory controlled by the self-proclaimed ‘republics’ (27: two killed and 25 injured), and 15.6 percent (five: one killed and four injured) in Government-controlled territory. (https://reliefweb.int/report/ukraine/conflict-related-civili...)
The bulk of civilian casualties since 2014 has been in the rebel regions and inflicted by Ukrainian government forces.