I'm more of a waiter than interrupter, who lives with a strong interrupter. If we're having a debate or discussing the newest silly thing in the news or whatever, it's not a big deal -- the topic was never _that_ important that I care about getting interrupted.
However, I find it very rude and annoying to get interrupted while telling a story. Like, event XYZ happened on the drive home, or something that happened with others in our mutual friend group. It's only going to take a minute or two for me to tell the whole story, but 15 seconds in it's been hijacked and the interrupter is off on their own tangent.