Yeah this. My old 3700X rig would need to be power cycled 3-4 times before it booted. This turned out to be the Radeon GPU I chucked in it inflaming the boot sequence in some way. Put an nvidia one in and it was fine. The Radeon worked fine on another machine.
Own an M1 MacBook Pro now and never looked back at the hell of custom built PCs favourably.