Tirzepatide delivered up to 22.5% weight loss in obese or overweight adults
investor.lilly.com
investor.lilly.com
20% is huge. I have managed to reduce my longterm weight over a five to ten year period by 10% to 15% at best and have persisting issues in closing out some lingering weight. My partner is on near to starvation diet, concerned about micronutrients and bone loss and cannot shift weight easily on her current metabolism and activity levels, and we're both old and constrained for other reasons in exercise. We're in the overweight camp not obese or morbidly obese camp but would love not to be.
I do not want to be on a drug for weightloss but at a cost of some gastro intestinal discomfort for a window in time, to make a quantum leap down (and 20% is a significant amount) with consequent upsides to metabolic syndrome, fatty liver, hypertension, I would think about it.
Hopefully it's seen as a "one-time" treatment, and paired with improved exercise and eating habits, but I somehow doubt that will be the result.
The long term study on "The Biggest Loser" contestants has some interesting insights into this where contestants who lost lots of weight had slower metabolisms than other people in their same weight classes even years after losing the weight, whether they gained it all back or not.
In other words, a 150lbs person who never had to lose a lot of weight actually can eat more and work out less than a 150lbs person that lost 150lbs 5 years ago. Also, the resting burn rate was still lower in the contestants.
It's just a recipe for long term failure if your metabolism doesn't adjust and reset after weight loss.
People obsess about the idea that you can't "outrun your diet" but neglect the fact that a sedentary person is at all sorts of risk regardless of their diet.
Obesity is a major cause of long term health issues in the US and other developed countries.
63% on the highest dose achieved a 20% body weight reduction. If you imagine morbidly obese people weighing in at 300, 400 lbs, that's 60-80 lbs of weight loss.
That said I agree that something like this, assuming results hold, no drawbacks, etc could be very valuable, if nothing else just for increasing quality of life. But I could see that losing an initial chunk of weight also helping on the road to exercise (if you are extremely overweight exercise may not be an option).
When I see families at the supermarket checking out with nothing but candies and processed junk food I die a little bit inside, the veggies aisle is 1/10th of the supermarket, the candies aisle is twice as big, the biscuit aisle too, the purposefully put colorful candies and junk food packages at children eyes level near the cash registers, &c.
We're selling them the addiction and now we're attempting to sell them the cure, it's not fantastic, it's vile
From sugar to processed food, carcinogenic additives, alcohol, tobacco, it's not a secret, it's very well documented...
Selling shit that shaves of decades of your life is an utopia, controlling them is "authoritarianism"... I'm glad I have the will power to not fall into that but clearly the vast majority of the population doesn't, what are we waiting for ? 100% obesity rate ? our lifestyles and especially our diets are an insult to nature
"my body my choice" they will say, ok then fuck off of the public healthcare system because I'm not financing your slow suicide
There are still people who think that food is not to blame.
No one was fat 150 years ago.
What do you think will happen if people start gobbling up these pills while still eating garbage? It will just mask the damage being done to the body.
Meanwhile big pharma will be rolling in cash while people will end up destroying their bodies even more.
If I can not exercise and take a pill to replicate the benefits of cardio and strength training, I’d also do that. I only have so many hours left to live, and I’d rather not spend it doing maintenance on my body.
Life is short. I want all the benefits without the costs (time, restraint), and if science can make it happen, shut up and take my money. To argue there’s a moral hazard here is…strange, if we have the capability and the side effects can be managed.
Just don't be suprised when in 20 years "the science" will tell you that they were wrong (again) lol.
Caloric surplus is not a new phenomenon, ancient Rome had obesity.
It’s definitely become much easier to gain a surplus with all this processed food but I just don’t see behaviors changing anytime soon, so anything that reduces the pressure on our health care systems is worth investigating.
You can easily gain weight eating too much healthy food.