Ask HN: is it just my eyes?

Is it just my eyes or do you have trouble getting your web designs to look good on windows?

I don't know what rendering engine windows uses to render colours but it's very difficult to get colours that don't look sickly when viewed on various PCs. I'm not talking about images as such (although they always just look mediocre) but CSS designs that no amount of tuning can liven them up.

What's your experience?