The "5,472,730,538" is the number of different (under symmetry) completed grids -- so are we saying we could make a (hypothetical) book with 5,472,730,538 completed grids and say "Here is all your Sudoku"? Or, that we are only allowed to create exactly one Sudoku from each finished grid? Neither of those seem like reasonable claims.
A more reasonable question would be, how many partially completed sudoku grids are there which have a unique solution. We don't know the answer to that.
Even if we did do that, I've done some research on measuring difficulty of Sudoku -- many Sudoku grids are unsolvable by humans -- they are far too hard.
A different, and interesting, question would be how many Sudoku are there which can be considered human-solvable. That's an even more open problem (we'd have to exactly define human-solvable to start).