From a physical and mental stand point, the work can be quite a lot. Amazon doesn't take it easy on you. However, after gaining some conditioning I enjoy being paid to spend time outside. It's confirmed that I need to take more serious look into fields that let me work outside.
To sustainably preform at my optimum, nutrition and recovery are essential. During "peak" (highest volume of pkgs moved) my watch will record anywhere from 10 - 14 mi a day of walking with over a +1,000 calories burned.
Navigating streets with tourist, delivering on hills with significant grades, abnormal addresses and entrances (it's never quite as straightforward as one might think), numerous not up to code unique hazards, and what can be daily route changes - [one day delivering to skyscrapers in the Financial, the next to apartments in the Tenderloin) makes for a stimulating week of work.
It's not for everyone but can be rewarding while allowing a more focused split between work/life rather than where you're never really "off" from work.