It depends on the anti-cheat systems. Some games are significantly easier to cheat in than others for rather obvious reasons. Anti-cheat has a very hard problem in that you're shipping your binary to an obviously-hostile environment where people will do anything and then some to get the upper hand.

If you attended Kernel and Hardware hacking courses at security trainings, you're likely sitting next to either some cheat developers, or some anti-cheat team members.