The entire point of advertising is manipulating human beings. Targeted advertising means you have even more data specific to an individual making it easier to manipulate the individual. More generic advertising (for example, TV ads) means all you have is the general area they live in, or the general interest of the individual (magazine ads). You cannot manipulate people based on their personal traits anymore.
The focus of the advertising shifts immediately from the consumer of the ad to the product and/or message of the ad, because you simply do not have enough information about the consumer.