Shame uMatrix is dead, but I use it to allow javascript for the local domain, and disable for third-party domains by default. It allows me to use at least some websites without too much fiddling with the uMatrix settings.
Edit: After setting advanced mode, hit ctrl twice in the popup to get the green/gray/red filtering. https://github.com/gorhill/uBlock/wiki/Dynamic-filtering:-qu...
I'm using it now, and it's IMO hands down *the absolute best extension I have ever used*.
uMatrix >> (uBO | noScript | privacy badger | cookie ninja | cookie autodelete | etc)
I use all of them along with vimium-ff and midnightlizard, but uMatrix is by far the best idea for managing what is run for better privacy and performance of browsing.
[0] https://www.ghacks.net/2020/09/20/umatrix-development-has-en...
[1] https://www.ghacks.net/2021/07/15/umatrix-has-an-unfixed-vul...
It's quite nice though. I have it set to disable any and all third party resources by default and from there it's generally fairly easy to permit the necessary things the first time I visit a site. And if it proves to be difficult I generally just decline to use that website at all.