Yes, as long as it was in the best interest of the Fedora project. A recent example IMHO is the change of default filesystem to btrfs. From Red Hat's perspective a default like XFS or stratis would be better as it would provide more testing/adoption for their recommended RHEL uses. Another might be the creation of a Fedora Server variant which isn't really in the interest of Red Hat.
If there were something good for Fedora that would really hurt Red Hat, I wouldn't expect it to happen, but I can't think of anything that wouldn't also be bad for Fedora. Maybe a Fedora LTS version, but there are other already extant options to address that market so I don't see a need there. I would like to see a Fedora LTS kernel version though that behaved more like Ubuntu's.