I was writing an NMEA parser today. (NMEA 0183 is a common serial GPS data protocol) My serial port reads returned an IOvec-like type which exposed limited operations. I spent probably an hour making helper functions and doing various verification and parsing operations on the IOvec type because it saved having to copy the data into a contiguous buffer. Midway through I stopped and realized that I would only need to copy when the ~50B message straddled the end of the ~64kB buffer. It takes a few nanoseconds to copy 50B. I spent an hour on an optimization that would never do anything but complicate the code. If I had just written the simple and obvious code, and spent that hour profiling the application to optimize what would actually make a difference, I'd be much better off.
That is what the quote is talking about. I don't think you can blame the quote if people are just ignoring the first word, and I'm not convinced that's actually a common thing.