ts-node is good enough to stick to Node for now if you want TypeScript. I don't think the rest of Deno is that compelling, although I would probably switch to Deno once its Node compat is awesome since it is a more compelete package out of the box than Node is.
Deno's battle is that it is an incremental improvement, and competing JS runtimes is quickly become the new JS web framework meme alternative (Bun, Boa, Node, Deno)