Every author of a manuscript should have full faith and knowledge of the results and presented data, but in a massive piece of work such as this, how can you? Imagine for a second, one graduate student doesn't want to face the wrath of an Assistant Professor one day, on purpose or not mishandles data. A year or two later it turns out you have not only wasted your time, but also the time of 500+ citing paper authors, numerous grant proposals, etc. Alongside the Alzheimer's retraction this year, the thirst for impact factor and the problems this causes seems to be yet another unsolvable problem in academia.