I'm surprised this isn't mentioned here more clearly: Some high end cases like the be quiet silent base I'm using have the option to mount the graphics card vertically, basically parallel to the mainboard, in a separate anchor slot. It needs an additional connector cable (~$20), but other than that is easy to setup, looks better with a look-in case (the illuminated fans face the glass side) and the weight pulls on a special anchor point just for that with no electronics involved. Plus the card itself is more sturdy in that orientation and there is no issues with bending through its own weight. It might even be beneficial ventilation-wise as the graphics card no longer causes a horizontal divide (basically creating separate ventilation-zones on the top and bottom of the card).
Yes, the cable will add approximately ~0.3ns of additional latency due to the added 10cm of distance.
This is how it looks like:
https://www.hardware-journal.de/images/Bilder/2018/test/be-q...
https://www.hardware-journal.de/images/Bilder/2018/test/be-q...