Not Nature but Molecular Systems Biology [2], apologies, in the context of reverse docking for antibiotics discovery:

"We confirm extensive promiscuity, but find that the average area under the receiver operating characteristic curve (auROC) is 0.48, indicating weak model performance."

Derek Lowe had a post about this earlier this month [1] (which includes important qualifications I failed to omit).

[1] "Benchmarking AlphaFold-enabled molecular docking predictions for antibiotic discovery", Molecular Systems Biology 2022 18:e11081 https://doi.org/10.15252/msb.202211081

[2] "Not AlphaFold's Fault", September 7 2022, https://www.science.org/content/blog-post/not-alphafold-s-fa...

Sorry, you don't know what you're talking about. Nobody is truly claiming these models can be used directly for drug discovery (well, some people claim that; but they're wrong). We already knew that, though- the same problem exists with high quality crystal structures.

What would be more interesting is if we did a whole bunch of crystal or cryo-EM structures far from what we've previously determined and demonstrate whether alphafold could make out-of-class predictions for them.

Do you have links to that? have not seen those.