So for any of these destinations there are really two options: fly-by or orbit insertion.
Pluto obviously was a fly-by. There were several reasons for this. Distance is a big one. Also, the more distant planets are the lower their orbital velocity. More distance = longer travel time. A higher velocity can reduce the travel time but you need to speed up at launch and slow down on arrival and that requires a higher delta-V budget. That requires extra mass of fuel, which becomes a vicious circle.
Pluto is tiny and far so a fly-by was really the only option. Even then it took 10 years to get there.
Neptune is more massive, closer and heavier. All of these help but if I'm reading [1] correctly, you'd still be realistically looking at a 30 year travel time for an insertion orbit. Having instruments hibernate for that long and work on the other end is really the biggest problem.
We're entering an era of super-heavy lifters. Maybe these will meaningfully increase the practical delta-V budgets.
Inserting a probe into orbit around Uranus (let alone Neptune) seems currently impractical just given how long it would take but that doesn't make me want it any less. Even a fly-by is better than nothing.
But the delta-V for Saturn, Uranus and Neptune are all roughly the same
[1]: https://en.wikipedia.org/wiki/Delta-v_budget