Static modules are loaded as shared libraries/dlls. The way operating systems implement this is that each library is loaded once per process and that statically allocated memory is mapped into the virtual address space of the process. You can't load one so/dll multiple times in some sort of container, so each module would have to implement this isolation inside their module, probably through some sort of API that the python runtime offers to the module. It's not rocket science but it will definitely break existing code where it's common practice to use dll lifetime hooks as initialization code that allocated some global state that's conveniently shared throughout the module.

It's all a single process, and native modules are just shared libraries, so how would it allocate multiple instances for different interpreters?