A new JavaScript framework is not "the next big thing". It's the next thing that everybody's going to jump on as a bandwagon, but that's not the same thing at all.
The actual next big thing? Not a language. Not some hardware change ( I mean, ARM servers could be big, but only the server people will care. It won't be the Next Big Thing.) Not block chain - that's close to played out. Not machine learning - that's too far along. It's what's now, not what's next.
I see two possibilities. It might be quantum computing. I doubt it, but it might be. It also might be wearable VR. Again, I kind of doubt it, but I doubt it less than I do quantum.