Don't many/most drugs have known side effects and we literally are "playing statistics" with the tradeoff between the good the drug does on one hand and rare, sometimes fatal side effects on the other hand?
"C. difficile is a type of bacteria (germ) that causes diarrhea linked to at least 14,000 American deaths each year. When you take antibiotics, good bacteria that protect against infection are destroyed for several months. During this time, you can get sick from C. difficile. The bacteria can be picked up from contaminated surfaces or spread from the healthcare environment. People, especially older adults, are most at risk who take antibiotics and also get medical care."
-https://my.clevelandclinic.org/health/drugs/16386-antibiotic...
Meanwhile 150 people anually die of Tylenol: https://www.theatlantic.com/national/archive/2013/09/150-ame...