For iOS and iPadOS, I use Adguard Premium(they offer system wide blocking too). On Mac, Adguard for Safari is good enough. It’s the best possible option given Safari’s limitations if you want to stick with Safari. For most intents and purposes it works ‘almost’ as well as ublock origin on Firefox.
1Password and Wipr does a good job too.
Wipr seems to work pretty well. It doesn't block the stupid overlays that YouTube puts over the last 20 seconds or so of videos (not ads, but watch this or this next or subscribe to this channel...), but I don't think that uBlock does either.
AdGuard is alright and seems to work fine on YouTube.
iOS Safari has ad blockers in the app store now. I would be surprised if these aren't available for desktop Safari.