No. A cheat developer could still just sign a driver like every other developer and load a hypervisor. Then hook everything you want and youre gucci.

Another option: there are a lot of vulnerable drivers, such as intels LAN driver, or capcoms. Of course those are blacklisted and anti cheats usually don’t let you start the game when those are loaded, but you can use exploitable those to load your own driver, and then unload the vulnerable driver.

Other things you can do: DMA stuff, uefi payloads and more.

You will never be able to prevent cheating on user owned hardware which sits under their desk.