It's not difficult, but it's disrupting to your coding flow, which is bad in itself and even worse when prototyping.
If it gets to 2-5 minutes the likelihood that you stop writing tests and rely on the compiler for bugfreeness goes up - or the likelihood that you create debt by increasing the complexity of your code organization.
And juggling variables was an ongoing ordeal when I tried. I can't imagine how you would work on code without changing any of the variables.
Compile times of 2-5 minutes can happen in langs that are not rust. You mentioned rust, not me. And anyways the 30s to hn thing is real.
You can leave those "unused variable" warnings and fix them before release
The difference is that warnings are visible, the underscores however suppressed the compiler's ability to help you.