A kilogram is a lot, considering LSD is active at microgram doses, although in practice there are labs producing and handling kilograms of it.

LSD in powder form is readily available on the black market. Expensive (because you don't just go and ask to buy only 1mg of LSD powder), but not exceptionally unsafe or rare.

Now the people who handle Fentanyl and Fentanyl analogues, those probably want to triple check their gloves and mask before putting them on.