Without the option to crash - you aren't a pilot.
If and when we find the secret to immortality - this right to end your own life how you see it will be eroded by corporate greed.
Tangential point, back to the main one.
There are 2 classes of drugs I would not legalize and you named one of them. the opioid and amphetamine are a chemical moth to the flame trap - And I support making that trap harder to find/get into...
Psychs on the other hand, RC's of course are dangerous due to their inherent novelty, Don't do the same things as Meth/fentanyl/crack, and generally are less dangerous/abusable. Basically anything that rewires the dopamine reward circuit should be highly suspect at best - and banned at worst.
Most psyches build a tolerance quickly in the brain - resulting in weeks/months between effective 'trips'. To abuse psyches is tough - and not desirable (after a trip most people want a rest for a long while from doing that again)
Yeah - freedom of brain chemistry should also be an unalienable right. If the government tells you what is allowed brain chemistry and what is not: that's government mind control...
If someone controls what you ingest, see and hear: they control (to some extent) what you think.