But I have frequently seen them being used when class instances would be better suited.
Dictionaries' values cannot be replaced with methods via @property, and as a result, I've found they often need to be replaced with objects at some point. DStruct is a response to that problem where your access interfaces aren't forwards-compatible with the great majority of types you might choose in the future (ORM/ODM instances are a big one).
But I've also found it quite useful in the other direction: when replacing what was once an ORM/ODM class with something mocked (e.g. the data source that was once a database has become a remote resource, local file, parser output, or configuration dict), having to run around changing attribute accessors to dict accessors is a drag at best, and impossible at worst (e.g. If you were using @property extensively to return computed attributes, or you know at hydration time that code elsewhere relies on a schema (I do both a times, as anyone writing large, maintainable applications should.).
As another commenter also mentioned, my approach does yield prettier code.
While it's not always sufficient cause, prettier code is in fact a good thing.