You only need 62 glyphs for a basic Latin alphabet including case (although gutenberg’s german would require a few more), but you need a lot of copies of each to lay a complete page, and they’d lay multiple pages per sheet.
Not to mention because character frequencies are not equal you need a lot more of some than others so you might have a multi-type matrix of just Es in order to cast enough of those for your needs in a reasonable time frame.
Gutenberg's bible used ligatures and various symbols too, that ups the count a lot. I haven't counted them myself, but wikipedia says 290 characters and cites John Man's book about Gutenberg. A paper I found about using ML to do cluster analysis on the glyphs says 299 unique glyphs and cites Gottfried Zedler. I can't read either of those sources, but a bit less than 300 seems like a safe bet.
https://en.wikipedia.org/wiki/Gutenberg_Bible#Type
https://deepai.org/publication/classifying-the-typefaces-of-...