I just had to do a site which involved a fair amount of interactivity. A sidebar with different types of filters, a search bar at the top, and a complex boolean filter builder inside a modal (think like infinitely-nestable AND/OR filters, where each filter involved 5 dropdowns interacting with each other). Then some area to collect the results and do some operations on them. I was feeling brave and decided to skip Vue which we otherwise use for complex UIs and do the whole page with HTMX and nothing else. And it worked.

It took me longer, thats for sure, but also because I had to get a feeling for how to approach many things I would have just routinely plumbed together with Vue. And the feeling at the end was really satisfying, a fast-loading, complex interactive page, powered by ~10kb of Javascript, with all filtering logic, validation etc. completely server-side (we use ASP.net). And I have confidence it will work exactly as it is years from now. With our Javascript tooling, I expect things to break by that time.

That said, I certainly pushed the library in parts, and the vote is still out on how easy it will be to understand the flow of interaction if some time has passed.