Overdose is disproportionately high though[1]. I mean, take a stroll thru most American cities and you can see what a toll drug use has done to many many people.
Outside of the cities, the opioid crisis has claimed the lives of millions. I have had friends and family die from overdose and complications from over-prescription.
It’s no secret; addressing the problem would cost drug manufacturers billions, which is why nothing is being done IMO
[1]: https://www.commonwealthfund.org/blog/2022/overdose-deaths-s...