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Comment by evo_9 | Hacker News Reader

I'm a month into taking rapa and already I feel like it's having a noticeable effect. I'm curious what others on this threads dosage looks like. If you prefer to keep it private, you can email me directly (my email is on my profile).

I'm currently taking 2mg once a week on my rest day; I started with 1mg and after 1 month added another MG. I'll continue each month until I reach 8MG once a week, which is the dosage the doc I worked with in Texas to get my prescription recommended and most people seem to take.

Also - I would say that NMN + Rapa is a completely life altering combination for anyone 50+. I feel like I can lift harder and longer now than when I was in my 40's and things seem to be getting easier the farther into my rapa routine I get.

Also also - you can find rapamycin online / overseas under its other name - Sirolimus - and the cost is a little lower than getting a proper US prescription.

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I have been taking Rapamycin for 19 weeks and NR and Metformin (for anti-aging) for much longer and I can't see any difference. I'm 50+. I generally, however, feel excellent, as well as I remember when I was younger so long as I have gotten lots of sleep and don't have a cold. When I'm sick or tired I feel much worse than I did, however.

Finding a doctor who's up to "non-traditional" support can be a challenge, but you've inspired me to start that search.

Besides satisfying their altruism they have nothing to gain and everything to lose if this miracle drug causes cancer in 5 years.

I read up ok it. It can literally cause cancer.

Which one, NMN or Rapa?

Depending on where you are, everything can cause cancer.

This website is known to the State of California to cause cancer.

One of the additives I work with in pottery is labeled with a prop 65 warning. The only ingredient is silicon dioxide, aka sand.

Which can lead to silicosis, which itself then leads to lung cancer.

This is also used as an anti-caking agent in food. Does CA label foods in that manner? Seems like it would cause confusion for the average consumer.

This doctor will prescribe it, he does telemed / remote calls, works out of Texas: https://www.theprivatepractices.com/services/rapamycin

What's NMN?

Nicotinamide Mononucleotide, an unregulated supplement.

Note also:

> We found that, when data from all organisms studied were combined for each compound, aspirin resulted in the highest percent increase in average lifespan (52.01%), followed by minocycline (27.30%), N-acetyl cysteine (17.93%), nordihydroguaiaretic acid (17.65%) and rapamycin (15.66%), in average.[0]

Though I'd consider whether flies and worms are good models for your human self.

0: https://pubmed.ncbi.nlm.nih.gov/34687363/

Is NMD related to NAD+?

Yes, it is a precursor to NAD

See also B3 (niacin aka nocotinic acid) in the Krebs cycle.

Thanks!

> Though I'd consider whether flies and worms are good models for your human self.

Even other vertebrates don't share the human cancer model, so people are absolutely jumping the gun assuming that this generalises to us.

But I'd imagine (and hope) that it's mostly laymen (and quacks in the supplement business) that are pushing the notion that the evidence is in?

Yeah as others appointed out it’s a nad+ precursor.

I feel compelled to comment though because anytime I read about how this stuff is only been tested in worms in mice… That automatically discount it’s worth as something to consider.

I’m gonna sah what I said before - I’ve played high-level hockey my whole life, I’m now 55 and I play against guys that barely washed out of their pro career.

When I stop taking nmn for two months my speed dropped from 20+ Mph to the mid teens.

A week after resuming my NMN supplementation my speeds are back in the 23-24 mph range

There’s just no way to fake it against players of this caliber. And to be clear I don’t know anybody even close to my age competing at this level.

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