Expansion: in non-tempered, natural tuning, such as often used when playing a violin, there are differences between some sharps and flats built from different notes, because natural harmonic intervals, based on frequency ratios like 3:2, do not split the frequency range in a completely log-linear way. This is why, say, G# and Ab may be not the same for purposes of pure natural harmony [1].
Equal temperation was invented to overcome this. J.S.Bach wrote a great showcase for it, Woll-Tepmeriertee Klavier, which involves harmonies and chord progressions that are hard or impossible to achieve with natural tuning without producing weird dissonances.