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Comment by kallistisoft | Hacker News Reader

I find that effective dosage is the most surprising aspect of this study

>Interventions Study medications were psilocybin, 25 mg/70 kg, vs diphenhydramine, 50 mg (first session), and psilocybin, 25-40 mg/70 kg, vs diphenhydramine, 50-100 mg (second session). Psychotherapy included motivational enhancement therapy and cognitive behavioral therapy.

25mg is an extremely small dose! Much smaller than most micro-dose regiments at 0.5g

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No, 0.5g is the weight of a dried mushroom for microdosing.

From another article I read:

> Common varieties such as Psilocybe cubensis and Psilocybe semilanceata contain around 6 -10mg of psilocybin per gram of dried mushrooms

So a 25mg dose of psilocybin is on the order of 2.5 - 4 grams of dried mushrooms, which is a hefty amount.

25mg is not a small dose if you're actually measuring the psilocybin rather than the dried weight of the mushroom fruit. The exact psilocybin weight ratio depends on the strain of mushroom, but typically dried P. Cubensis is about 1% psilocybin by weight. This means that 25mg of psilocybin roughly corresponds to 2.5g of dried shrooms.

The previous comment (~4g) is correct, most studies have put standard cubes at around 0.6% psilocybin.

https://www.leafly.com/learn/psychedelics/how-to-dose-mushro...

They are measuring how much psilocybin (the compound) while people normally measure how much dry mushrooms by weight

Are you perchance going by weight of dried fruit?

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