For my use I tend to run a high performing Windows VM (very good with most games and other GPU accelerated programs - even chrome/adobe these days uses the GPU) inside Linux.
This can also be used for various high assurance use cases such as OpenXT / QubesOS (security by compartmentalization). For example a laptop computer being used by an automotive company for CAD to keep their information safe from other programs on the system (like a browser in another VM) the prying eyes of competitors. I made a video of that here:
https://news.ycombinator.com/item?id=32585333
We have also been working on something called "LIME Is Mediated Emulation" which is a Win64 binary compatibility layer similar to WINE but using vGPUs. You can read about that here: