Real scenario - developer of Valheim initially released the game on Itch.io but then removed it from there, saying that it now has to rely on Steam services for NAT traversal for its multiplayer, making it tied to Steam in result.
Clearly if IPv6 would have been available there wouldn't have been the need for such services, no? So I'd say end users are bitten by this, just not in obvious ways for them to start complaining about it.