PKD there ['drugs so powerful reality itself changes'] is getting into the concept of the immersion of the self in a perceived reality, one of the major themes he returns to over and over.
It can be a difficult concept to grasp for those who've lived their entire lives immersed in one single viewpoint (religious fundamentalists for example). In such cases, it's rather like trying to explain what 'wet' means to a fish. The fish has never experienced 'not-wet', and so has no notion that it's immersed in anything - that's just its perceived reality. Hence the 'take the fish out of the water' concept can be seen as a kind of deprogramming, in PKD's view, or escaping the brainwashing imposed by authoritarian socieites of all stripes. There are those who ardently argue against this kind of thinking, curiously enough - for example, they'll say we should tell historical lies to children in the name of enhancing their faith in their political leaders and state institutions.
In terms of actual physical reality, though, humans have tended to rely on shared experience of global external state, in the programmer's lingo. Internal object state has to be tested against other's perceptions, which is why if people hear or see something strange or out-of-the-ordinary, the first thing we do is ask someone else "Hey did you hear that? Did you see what I just saw?"
Now if others don't confirm our reality, we might worry about our mental state - i.e. auditory hallucinations are a well-known feature of schizophrenia, for example.